Ontology highlight
ABSTRACT:
SUBMITTER: Kakoki M
PROVIDER: S-EPMC516527 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
Kakoki Masao M Takahashi Nobuyuki N Jennette J Charles JC Smithies Oliver O
Proceedings of the National Academy of Sciences of the United States of America 20040823 36
Type I human diabetics and streptozotocin-induced diabetic mice with higher genetically determined levels of angiotensin-converting enzyme have an increased risk of developing nephropathy. However, previous experiments in mice and computer simulations indicate that modest increases in angiotensin-converting enzyme have minimal effects on blood pressure and angiotensin II levels, although bradykinin decreases significantly, inferring that bradykinin is critical for protecting the kidney in diabet ...[more]