Ontology highlight
ABSTRACT:
SUBMITTER: Gasa R
PROVIDER: S-EPMC516555 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
Gasa Rosa R Mrejen Caroline C Leachman Nathaniel N Otten Marc M Barnes Michael M Wang Juehu J Chakrabarti Swarup S Mirmira Raghavendra R German Michael M
Proceedings of the National Academy of Sciences of the United States of America 20040830 36
In the developing pancreas, the basic helix-loop-helix (bHLH) protein Neurogenin3 (Ngn3) specifies which precursor cells ultimately will become endocrine cells and initiates the islet differentiation program. NeuroD1, a closely related bHLH protein and a downstream target of Ngn3, maintains the differentiation program initiated by Ngn3. We have developed an in vitro model of Ngn3-dependent differentiation by infecting pancreatic duct cell lines with an Ngn3-expressing adenovirus. We found that b ...[more]