Ontology highlight
ABSTRACT:
SUBMITTER: Silva AM
PROVIDER: S-EPMC5166501 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Silva Ana M AM Osório Daniel S DS Pereira Antonio J AJ Maiato Helder H Pinto Inês Mendes IM Rubinstein Boris B Gassmann Reto R Telley Ivo Andreas IA Carvalho Ana Xavier AX
The Journal of cell biology 20161213 6
Cytokinesis in animal cells requires the constriction of an actomyosin contractile ring, whose architecture and mechanism remain poorly understood. We use laser microsurgery to explore the biophysical properties of constricting rings in Caenorhabditis elegans embryos. Laser cutting causes rings to snap open. However, instead of disintegrating, ring topology recovers and constriction proceeds. In response to severing, a finite gap forms and is repaired by recruitment of new material in an actin p ...[more]