Dataset Information
Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy.
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ABSTRACT:
SUBMITTER: Dondi R
PROVIDER: S-EPMC5166568 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy.
Organic & biomolecular chemistry 20161201 48
Efficient syntheses of cell-penetrating peptide-porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT). ...[more]