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Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy.

ABSTRACT: Efficient syntheses of cell-penetrating peptide-porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).

SUBMITTER: Dondi R

PROVIDER: S-EPMC5166568 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy.

Dondi R R Yaghini E E Tewari K M KM Wang L L Giuntini F F Loizidou M M MacRobert A J AJ Eggleston I M IM

Organic & biomolecular chemistry 20161201 48

Efficient syntheses of cell-penetrating peptide-porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT). ...[more]

PMID: 27886311

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