Ontology highlight
ABSTRACT:
SUBMITTER: McCarrey JR
PROVIDER: S-EPMC5167269 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
McCarrey John R JR Lehle Jake D JD Raju Seetha S SS Wang Yufeng Y Nilsson Eric E EE Skinner Michael K MK
PloS one 20161219 12
Exposure to environmental factors can induce the epigenetic transgenerational inheritance of disease. Alterations to the epigenome termed "epimutations" include "primary epimutations" which are epigenetic alterations in the absence of genetic change and "secondary epimutations" which form following an initial genetic change. To determine if secondary epimutations contribute to transgenerational transmission of disease following in utero exposure to the endocrine disruptor vinclozolin, we exposed ...[more]