Dental pulp stem cells express tendon markers under mechanical loading and are a potential cell source for tissue engineering of tendon-like tissue.
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ABSTRACT:
SUBMITTER: Chen YY
PROVIDER: S-EPMC5168414 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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Dental pulp stem cells express tendon markers under mechanical loading and are a potential cell source for tissue engineering of tendon-like tissue.
Chen Yu-Ying YY He Sheng-Teng ST Yan Fu-Hua FH Zhou Peng-Fei PF Luo Kai K Zhang Yan-Ding YD Xiao Yin Y Lin Min-Kui MK
International journal of oral science 20161216 4
Postnatal mesenchymal stem cells have the capacity to differentiate into multiple cell lineages. This study explored the possibility of dental pulp stem cells (DPSCs) for potential application in tendon tissue engineering. The expression of tendon-related markers such as scleraxis, tenascin-C, tenomodulin, eye absent homologue 2, collagens I and VI was detected in dental pulp tissue. Interestingly, under mechanical stimulation, these tendon-related markers were significantly enhanced when DPSCs ...[more]
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