Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Z
PROVIDER: S-EPMC5171825 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Zhao Zhikun Z Goldin Lynn L Liu Shiping S Wu Liang L Zhou Weiyin W Lou Hong H Yu Qichao Q Tsang Shirley X SX Jiang Miaomiao M Li Fuqiang F McMaster MaryLou M Li Yang Y Lin Xinxin X Wang Zhifeng Z Xu Liqin L Marti Gerald G Li Guibo G Wu Kui K Yeager Meredith M Yang Huanming H Xu Xun X Chanock Stephen J SJ Li Bo B Hou Yong Y Caporaso Neil N Dean Michael M
Nature communications 20161216
Chronic lymphocytic leukaemia (CLL) is a frequent B-cell malignancy, characterized by recurrent somatic chromosome alterations and a low level of point mutations. Here we present single-nucleotide polymorphism microarray analyses of a single CLL patient over 29 years of observation and treatment, and transcriptome and whole-genome sequencing at selected time points. We identify chromosome alterations 13q14-, 6q- and 12q+ in early cell clones, elimination of clonal populations following therapy, ...[more]