Are gene expression microarray analyses reliable? A review of studies of retinoic acid responsive genes.
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SUBMITTER: van der Spek PJ
PROVIDER: S-EPMC5171945 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
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Are gene expression microarray analyses reliable? A review of studies of retinoic acid responsive genes.
van der Spek Peter J PJ Kremer Andreas A Murry Lynn L Walker Michael G MG
Genomics, proteomics & bioinformatics 20030201 1
Microarray analyses of gene expression are widely used, but reports of the same analyses by different groups give widely divergent results, and raise questions regarding reproducibility and reliability. We take as an example recent published reports on microarray experiments that were designed to identify retinoic acid responsive genes. These reports show substantial differences in their results. In this article, we review the methodology, results, and potential causes of differences in these ap ...[more]
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