The evolutionary relationship of the domain architectures in the RhoGEF-containing proteins.
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ABSTRACT:
SUBMITTER: Sun QL
PROVIDER: S-EPMC5172558 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Publications
The evolutionary relationship of the domain architectures in the RhoGEF-containing proteins.
Sun Qing Lan QL Zhou Hong Jun HJ Lin Kui K
Genomics, proteomics & bioinformatics 20050501 2
Domain insertions and deletions lead to variations in the domain architectures of the proteins from their common ancestor. In this work, we investigated four groups of the RhoGEF-containing proteins from different organisms with domain architectures RhoGEF-PH-SH3, SH3-RhoGEF-PH, RhoGEF-PH, and SH3-RhoGEF defined in the Pfam database. The phylogenetic trees were constructed using each individual domain and/or the combinations of all the domains. The phylogenetic analysis suggests that RhoGEF-PH-S ...[more]
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