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Androgen receptor expression predicts different clinical outcomes for breast cancer patients stratified by hormone receptor status.


ABSTRACT: In this study we sought to correlate androgen receptor (AR) expression with tumor progression and disease-free survival (DFS) in breast cancer patients. We investigated AR expression in 450 breast cancer patients. We found that breast cancers expressing the estrogen receptor (ER) are more likely to co-express AR compared to ER-negative cancers (56.0% versus 28.1%, P < 0.001). In addition, we found that AR expression is correlated with increased DFS in patients with luminal breast cancer (P < 0.001), and decreased DFS in TNBC (triple negative breast cancer, P = 0.014). In addition, patients with HR+ tumors (Hormone receptor positive tumors) expressing low levels of AR have the lowest DFS among all receptor combinations. We also propose a novel prognostic model using AR receptor status, BRCA1, and present data showing that our model is more predictive of disease free survival compared to the traditional TMN staging system.

SUBMITTER: Jiang HS 

PROVIDER: S-EPMC5173059 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Androgen receptor expression predicts different clinical outcomes for breast cancer patients stratified by hormone receptor status.

Jiang He-Sheng HS   Kuang Xia-Ying XY   Sun Wei-Li WL   Xu Yan Y   Zheng Yi-Zi YZ   Liu Yi-Rong YR   Lang Guan-Tian GT   Qiao Feng F   Hu Xin X   Shao Zhi-Ming ZM  

Oncotarget 20160701 27


In this study we sought to correlate androgen receptor (AR) expression with tumor progression and disease-free survival (DFS) in breast cancer patients. We investigated AR expression in 450 breast cancer patients. We found that breast cancers expressing the estrogen receptor (ER) are more likely to co-express AR compared to ER-negative cancers (56.0% versus 28.1%, P < 0.001). In addition, we found that AR expression is correlated with increased DFS in patients with luminal breast cancer (P < 0.0  ...[more]

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