Ontology highlight
ABSTRACT:
SUBMITTER: Han SY
PROVIDER: S-EPMC5173148 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Han Shu-Yan SY Han Hai-Bo HB Tian Xiu-Yun XY Sun Hong H Xue Dong D Zhao Can C Jiang Shan-Tong ST He Xi-Ran XR Zheng Wen-Xian WX Wang Jing J Pang Li-Na LN Li Xiao-Hong XH Li Ping-Ping PP
Oncotarget 20160701 27
MicroRNAs (miRNAs) have been shown to function as either oncogenes or tumor suppressors by negatively regulating target genes involved in tumor initiation and progression. In this study, we demonstrated that down-regulation of miR-33a-3p in human primary hepatocellular cancer (HCC) specimens was significantly associated with metastases and poor survival. Over-expression of miR-33a-3p in HepG2 cells remarkably suppressed not only cell growth, migration and invasion, but also tumor growth and meta ...[more]