Ontology highlight
ABSTRACT:
SUBMITTER: Cech JN
PROVIDER: S-EPMC5173417 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 20160823 4
Having one and only one centromere per chromosome is essential for proper chromosome segregation during both mitosis and meiosis. Chromosomes containing two centromeres are known as dicentric and often mis-segregate during cell division, resulting in aneuploidy or chromosome breakage. Dicentric chromosome can be stabilized by centromere inactivation, a process which reestablishes monocentric chromosomes. However, little is known about this process in naturally occurring dicentric chromosomes. Us ...[more]