Ontology highlight
ABSTRACT:
SUBMITTER: Deng W
PROVIDER: S-EPMC5173435 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Deng Wenhai W Yang Jialong J Lin Xingguang X Shin Jinwook J Gao Jimin J Zhong Xiao-Ping XP
Journal of immunology (Baltimore, Md. : 1950) 20161123 1
Alveolar macrophages (AMϕ) have the capacity of local self-renewal through adult life; however, mechanisms that regulate AMϕ self-renewal remain poorly understood. We found that myeloid-specific deletion of Raptor, an essential component of the mammalian/mechanistic target of rapamycin complex (mTORC)1, resulted in a marked decrease of this population of cells accompanying altered phenotypic features and impaired phagocytosis activity. We demonstrated further that Raptor/mTORC1 deficiency did no ...[more]