Ontology highlight
ABSTRACT:
SUBMITTER: Chen WC
PROVIDER: S-EPMC5174132 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Chen Wei-Chun WC Tseng Chin-Kai CK Chen Bing-Hung BH Lin Chun-Kuang CK Lee Jin-Ching JC
Frontiers in pharmacology 20161221
Hepatitis C virus (HCV) infection is a causative factor leading to hepatocellular carcinoma due to chronic inflammation and cirrhosis. The aim of the study was first to explore the effects of grape seed extract (GSE) in HCV replication, and then to study mechanisms. The results indicated that a GSE treatment showed significant anti-HCV activity and suppressed HCV-elevated cyclooxygenase-2 (COX-2) expression. In contrast, exogenous COX-2 expression gradually attenuated antiviral effects of GSE, s ...[more]