Ontology highlight
ABSTRACT:
SUBMITTER: Watkinson TG
PROVIDER: S-EPMC5174144 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Watkinson Thomas G TG Calabrese Antonio N AN Ault James R JR Radford Sheena E SE Ashcroft Alison E AE
Journal of the American Society for Mass Spectrometry 20160624 1
Amphipols are a class of novel surfactants that are capable of stabilizing the native state of membrane proteins. They have been shown to be highly effective, in some cases more so than detergent micelles, at maintaining the structural integrity of membrane proteins in solution, and have shown promise as vehicles for delivering native membrane proteins into the gas phase for structural interrogation. Here, we use fast photochemical oxidation of proteins (FPOP), which irreversibly labels the side ...[more]