Ontology highlight
ABSTRACT:
SUBMITTER: Warner MJ
PROVIDER: S-EPMC5175334 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Warner Matthew J MJ Bridge Katherine S KS Hewitson James P JP Hodgkinson Michael R MR Heyam Alex A Massa Bailey C BC Haslam Jessica C JC Chatzifrangkeskou Maria M Evans Gareth J O GJ Plevin Michael J MJ Sharp Tyson V TV Lagos Dimitris D
Nucleic acids research 20160712 20
MicroRNAs (miRNAs) are short non-coding RNAs that silence mRNAs. They are generated following transcription and cleavage by the DROSHA/DGCR8 and DICER/TRBP/PACT complexes. Although it is known that components of the miRNA biogenesis machinery can be phosphorylated, it remains poorly understood how these events become engaged during physiological cellular activation. We demonstrate that S6 kinases can phosphorylate the extended C-terminal domain of TRBP and interact with TRBP in situ in primary c ...[more]