Ontology highlight
ABSTRACT:
SUBMITTER: Etheve L
PROVIDER: S-EPMC5175364 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Etheve Loïc L Martin Juliette J Lavery Richard R
Nucleic acids research 20160921 20
We have studied the dynamics of three transcription factor-DNA complexes using all-atom, microsecond-scale MD simulations. In each case, the salt bridges and hydrogen bond interactions formed at the protein-DNA interface are found to be dynamic, with lifetimes typically in the range of tens to hundreds of picoseconds, although some interactions, notably those involving specific binding to DNA bases, can be a hundred times longer lived. Depending on the complex studied, this dynamics may or may n ...[more]