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Assessment of the -174G/C (rs1800795) and -572G/C (rs1800796) Interleukin 6 Gene Polymorphisms in Egyptian Patients with Rheumatoid Arthritis.


ABSTRACT: AIM:This study aimed to investigate genotype and allele frequencies of -174 (rs1800795) and -572 (rs1800796) IL-6 promoter gene polymorphisms in Egyptian patients with rheumatoid arthritis (RA) in comparison to control group. METHODS:The study was conducted on 198 Egyptian subjects (99 RA patients and 99 healthy control). The promoter region of the IL-6 gene was amplified by PCR using DNAs from patients and the controls, and their PCR products were digested by suitable enzymes. RESULTS:No statistical differences were found in -572G/C genotype (P = 0.177) or allele (P = 0.147) frequencies between RA patients and controls. Significant differences were observed in -174G/C genotype (P < 0.001) and allele (P < 0.001) frequencies between RA patients and controls. CONCLUSION:A significant association of IL-6 -174G/C gene polymorphism and RA in Egyptian population was found with significantly higher frequencies of GC and CC genotypes and C allele in RA patients compared to controls. No association was found between IL-6 -572G/C gene polymorphism and RA.

SUBMITTER: Amr K 

PROVIDER: S-EPMC5175501 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Assessment of the <i>-174G/C</i> (rs1800795) and <i>-572G/C</i> (rs1800796) <i>Interleukin 6</i> Gene Polymorphisms in Egyptian Patients with Rheumatoid Arthritis.

Amr Khalda K   El-Awady Rehab R   Raslan Hala H  

Open access Macedonian journal of medical sciences 20161011 4


<h4>Aim</h4>This study aimed to investigate genotype and allele frequencies of -174 (rs1800795) and <i>-572</i> (rs1800796) <i>IL-6</i> promoter gene polymorphisms in Egyptian patients with rheumatoid arthritis (RA) in comparison to control group.<h4>Methods</h4>The study was conducted on 198 Egyptian subjects (99 RA patients and 99 healthy control). The promoter region of <i>the IL-6</i> gene was amplified by PCR using DNAs from patients and the controls, and their PCR products were digested by  ...[more]

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