Ontology highlight
ABSTRACT:
SUBMITTER: Abdelwhab EM
PROVIDER: S-EPMC5177941 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Abdelwhab E M EM Veits Jutta J Ulrich Reiner R Kasbohm Elisa E Teifke Jens P JP Mettenleiter Thomas C TC
Scientific reports 20161222
Acquisition of a polybasic cleavage site (pCS) in the hemagglutinin (HA) is a prerequisite for the shift of low pathogenic (LP) avian influenza virus (AIV) to the highly pathogenic (HP) form in chickens. Whereas presence of a pCS is required for high pathogenicity, less is known about the effect of composition of pCS on virulence of AIV particularly H7N7. Here, we investigated the virulence of four avian H7N7 viruses after insertion of different naturally occurring pCS from two HPAIV H7N7 (desig ...[more]