Osmotic and Heat Stress Effects on Segmentation.
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ABSTRACT:
SUBMITTER: Weiss J
PROVIDER: S-EPMC5179010 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Osmotic and Heat Stress Effects on Segmentation.
Weiss Julian J Devoto Stephen H SH
PloS one 20161222 12
During vertebrate embryonic development, early skin, muscle, and bone progenitor populations organize into segments known as somites. Defects in this conserved process of segmentation lead to skeletal and muscular deformities, such as congenital scoliosis, a curvature of the spine caused by vertebral defects. Environmental stresses such as hypoxia or heat shock produce segmentation defects, and significantly increase the penetrance and severity of vertebral defects in genetically susceptible ind ...[more]
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