Ontology highlight
ABSTRACT:
SUBMITTER: Henty-Ridilla JL
PROVIDER: S-EPMC5179141 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Henty-Ridilla Jessica L JL Rankova Aneliya A Eskin Julian A JA Kenny Katelyn K Goode Bruce L BL
Science (New York, N.Y.) 20160501 6288
Microtubules (MTs) govern actin network remodeling in a wide range of biological processes, yet the mechanisms underlying this cytoskeletal cross-talk have remained obscure. We used single-molecule fluorescence microscopy to show that the MT plus-end-associated protein CLIP-170 binds tightly to formins to accelerate actin filament elongation. Furthermore, we observed mDia1 dimers and CLIP-170 dimers cotracking growing filament ends for several minutes. CLIP-170-mDia1 complexes promoted actin pol ...[more]