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Glycosuria and Renal Outcomes in Patients with Nondiabetic Advanced Chronic Kidney Disease.


ABSTRACT: Sodium glucose cotransporter 2 inhibitors have shown a potential for renoprotection beyond blood glucose lowering. Glycosuria in nondiabetic patients with chronic kidney disease (CKD) is sometimes noted. Whether glycosuria in CKD implies a channelopathy or proximal tubulopathy is not known. The consequence of glycosuria in CKD is also not studied. We performed a cross-sectional study for the association between glycosuria and urine electrolyte excretion in 208 nondiabetic patients. Fractional excretion (FE) of glucose >4% was 3.4%, 6.3% and 62.5% in CKD stage 3, 4 and 5, respectively. These patients with glycosuria had higher FE sodium, FE potassium, FE uric acid, UPCR, and urine NGAL-creatinine ratio. We conducted a longitudinal study for the consequence of glycosuria, defined by dipstick, in 769 nondiabetic patients with stage 4-5 CKD. Glycosuria was associated with a decreased risk for end-stage renal disease (adjusted hazard ratio: 0.77; CI?=?0.62-0.97; p?=?0.024) and for rapid renal function decline (adjusted odds ratio: 0.63; CI?=?0.43-0.95; p?=?0.032); but glycosuria was not associated with all-cause mortality or cardiovascular events. The results were consistent in the propensity-score matched cohort. Glycosuria is associated with increased fractional excretion of electrolytes and is related to favorable renal outcomes in nondiabetic patients with stage 5 CKD.

SUBMITTER: Hung CC 

PROVIDER: S-EPMC5180243 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Glycosuria and Renal Outcomes in Patients with Nondiabetic Advanced Chronic Kidney Disease.

Hung Chi-Chih CC   Lin Hugo You-Hsien HY   Lee Jia-Jung JJ   Lim Lee Moay LM   Chiu Yi-Wen YW   Chiang Heng-Pin HP   Hwang Shang-Jyh SJ   Chen Hung-Chun HC  

Scientific reports 20161223


Sodium glucose cotransporter 2 inhibitors have shown a potential for renoprotection beyond blood glucose lowering. Glycosuria in nondiabetic patients with chronic kidney disease (CKD) is sometimes noted. Whether glycosuria in CKD implies a channelopathy or proximal tubulopathy is not known. The consequence of glycosuria in CKD is also not studied. We performed a cross-sectional study for the association between glycosuria and urine electrolyte excretion in 208 nondiabetic patients. Fractional ex  ...[more]

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