Coregulation of tandem duplicate genes slows evolution of subfunctionalization in mammals.
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ABSTRACT:
SUBMITTER: Lan X
PROVIDER: S-EPMC5182070 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Coregulation of tandem duplicate genes slows evolution of subfunctionalization in mammals.
Lan Xun X Pritchard Jonathan K JK
Science (New York, N.Y.) 20160501 6288
Gene duplication is a fundamental process in genome evolution. However, most young duplicates are degraded by loss-of-function mutations, and the factors that allow some duplicate pairs to survive long-term remain controversial. One class of models to explain duplicate retention invokes sub- or neofunctionalization, whereas others focus on sharing of gene dosage. RNA-sequencing data from 46 human and 26 mouse tissues indicate that subfunctionalization of expression evolves slowly and is rare amo ...[more]
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