Slowly eroding lesions in multiple sclerosis.

ABSTRACT:

Background

At autopsy, 20%-40% of chronic multiple sclerosis (MS) lesions are labeled "slowly expanding" and feature myelin phagocytosis at the lesion edge. As pathological lesion classification relies on a single, terminal time point, the rate of lesion expansion cannot be directly measured.

Objective

To study long-term volume changes in individual MS lesions.

Methods

Volumes of individual lesions on proton density magnetic resonance imaging (MRI) acquired between 1992 and 2015 were measured in 22 individuals (one lesion per person). After correction for acquisition protocol, a mixed model evaluated lesion volume changes.

Results

The mean (standard deviation) lesion volume at baseline was 142 (82) mL, falling to 74 (51) mL after 16 (3) years. All lesions shran

SUBMITTER: Sethi V 

PROVIDER: S-EPMC5182188 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature