Ontology highlight
ABSTRACT:
SUBMITTER: Paoletti F
PROVIDER: S-EPMC5183593 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Paoletti Francesca F de Chiara Cesira C Kelly Geoff G Covaceuszach Sonia S Malerba Francesca F Yan Robert R Lamba Doriano D Cattaneo Antonino A Pastore Annalisa A
Frontiers in molecular biosciences 20161226
Nerve Growth Factor (NGF), the prototype of the neurotrophin family, is essential for maintenance and growth of different neuronal populations. The X-ray crystal structure of NGF has been known since the early '90s and shows a β-sandwich fold with extensive loops that are involved in the interaction with its binding partners. Understanding the dynamical properties of these loops is thus important for molecular recognition. We present here a combined solution NMR/molecular dynamics study which ad ...[more]