Ontology highlight
ABSTRACT:
SUBMITTER: Krag TO
PROVIDER: S-EPMC518764 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
Krag Thomas O B TO Bogdanovich Sasha S Jensen Claus J CJ Fischer M Dominik MD Hansen-Schwartz Jacob J Javazon Elisabeth H EH Flake Alan W AW Edvinsson Lars L Khurana Tejvir S TS
Proceedings of the National Academy of Sciences of the United States of America 20040913 38
Duchenne's muscular dystrophy (DMD) is a fatal neuromuscular disease caused by absence of dystrophin. Utrophin is a chromosome 6-encoded dystrophin-related protein (DRP), sharing functional motifs with dystrophin. Utrophin's ability to compensate for dystrophin during development and when transgenically overexpressed has provided an important impetus for identifying activators of utrophin expression. The utrophin promoter A is transcriptionally regulated in part by heregulin-mediated, extracellu ...[more]