Ontology highlight
ABSTRACT:
SUBMITTER: Hu M
PROVIDER: S-EPMC5190034 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Hu Minghua M Wang Mingwei M Lu Huihong H Wang Xiaoming X Fang Xiaoshan X Wang Jinguo J Ma Chenyang C Chen Xiaobing X Xia Hongping H
Oncotarget 20160701 28
Hepatocellular carcinoma (HCC) is the leading cause of cancer related death worldwide. The number of deaths is proportional to the global incidence, which highlights the aggressive tumor biology and lack of effective therapies. Dysregulation of microRNAs has been implicated in carcinogenesis and progression of liver cancer. Here, we identified that miR-1258 was significantly downregulated in HCC and associated with poor patients' survival. Overexpression of miR-1258 significantly inhibits liver ...[more]