Ontology highlight
ABSTRACT:
SUBMITTER: Park J
PROVIDER: S-EPMC5190071 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Park Jino J Kim Soojin S Joh Joongho J Remick Scot C SC Miller Donald M DM Yan Jun J Kanaan Zeyad Z Chao Ju-Hsien JH Krem Maxwell M MM Basu Soumit K SK Hagiwara Shotaro S Kenner Lukas L Moriggl Richard R Bunting Kevin D KD Tse William W
Oncotarget 20160701 28
Constitutive STAT3 activation by tyrosine phosphorylation of mutated or amplified tyrosine kinases (pYSTAT3) is critical for cancer initiation, progression, invasion, and motility of carcinoma cells. We showed that AF1q is associated with STAT3 signaling in breast cancer cells. In xenograft models, enhanced AF1q expression activated STAT3 and promoted tumor growth and metastasis in immunodeficient NSG mice. The cytokine secretory phenotype of MDA-MB-231LN breast cancer cells with altered AF1q ex ...[more]