Ontology highlight
ABSTRACT:
SUBMITTER: Bonnin N
PROVIDER: S-EPMC5190076 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Bonnin Nathalie N Armandy Emma E Carras Julien J Ferrandon Sylvain S Battiston-Montagne Priscillia P Aubry Marc M Guihard Sébastien S Meyronet David D Foy Jean-Philippe JP Saintigny Pierre P Ledrappier Sonia S Jung Alain A Rimokh Ruth R Rodriguez-Lafrasse Claire C Poncet Delphine D
Oncotarget 20160701 28
At the time of diagnosis, 60% of patients with head and neck squamous cell carcinoma (HNSCC) present tumors in an advanced stage (III-IV) of disease and 80% will relapse within the first two years post-treatment, due to their frequent radio(chemo)resistance. To identify new molecular targets and companion biomarkers, we have investigated the miRNome of 75 stage III-IV oropharynx tumors without relapse (R) or with loco-regional relapse (non-responder, NR) within two years post-treatment. Interest ...[more]