Ontology highlight
ABSTRACT:
SUBMITTER: Obulkasim A
PROVIDER: S-EPMC5190081 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Obulkasim Askar A Ylstra Bauke B van Essen Hendrik F HF Benner Christian C Stenning Sally S Langley Ruth R Allum William W Cunningham David D Inam Imran I Hewitt Lindsay C LC West Nicolas P NP Meijer Gerrit A GA van de Wiel Mark A MA Grabsch Heike I HI
Oncotarget 20160701 28
Neoadjuvant chemo(radio)therapy followed by surgery is the standard of care for patients with locally advanced resectable esophageal adenocarcinoma (EAC). There is increasing evidence that drug resistance might be related to genomic heterogeneity. We investigated whether genomic tumor heterogeneity is different after cytotoxic chemotherapy and is associated with EAC patient survival. We used arrayCGH and a quantitative assessment of the whole genome DNA copy number aberration patterns ('DNA copy ...[more]