Ontology highlight
ABSTRACT:
SUBMITTER: Whitfield ML
PROVIDER: S-EPMC519100 | biostudies-literature | 2004
REPOSITORIES: biostudies-literature
Whitfield Michael L ML Kaygun Handan H Erkmann Judith A JA Townley-Tilson W H Davin WH Dominski Zbigniew Z Marzluff William F WF
Nucleic acids research 20040909 16
The stem-loop binding protein (SLBP) binds the 3' end of histone mRNA and is present both in nucleus, and in the cytoplasm on the polyribosomes. SLBP participates in the processing of the histone pre-mRNA and in translation of the mature message. Histone mRNAs are rapidly degraded when cells are treated with inhibitors of DNA replication and are stabilized by inhibitors of translation, resulting in an increase in histone mRNA levels. Here, we show that SLBP is a component of the histone messenge ...[more]