Nanoparticle transport and delivery in a heterogeneous pulmonary vasculature.

ABSTRACT: Quantitative understanding of nanoparticles delivery in a complex vascular networks is very challenging because it involves interplay of transport, hydrodynamic force, and multivalent interactions across different scales. Heterogeneous pulmonary network includes up to 16 generations of vessels in its arterial tree. Modeling the complete pulmonary vascular system in 3D is computationally unrealistic. To save computational cost, a model reconstructed from MRI scanned images is cut into an arbitrary pathway consisting of the upper 4-generations. The remaining generations are represented by an artificially rebuilt pathway. Physiological data such as branch information and connectivity matrix are used for geometry reconstruction. A lumped model is used to model the flow resistance of the branch

SUBMITTER: Sohrabi S 

PROVIDER: S-EPMC5191937 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature