Ontology highlight
ABSTRACT:
SUBMITTER: Henson KE
PROVIDER: S-EPMC5192128 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Henson Karl Evans R KE Yim Juwon J Smith Jordan R JR Sakoulas George G Rybak Michael J MJ
Antimicrobial agents and chemotherapy 20161227 1
The evidence for using combination therapy for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections is growing. In this study, we investigated the synergistic effect of daptomycin (DAP) combined with piperacillin-tazobactam and ampicillin-sulbactam against MRSA in time-kill experiments. Six of eight strains demonstrated synergy between DAP and the β-lactam-β-lactamase inhibitor (BLI) combination. In 5/8 strains, the synergy occurred only in the presence of the B ...[more]