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?-Lactamase Inhibitors Enhance the Synergy between ?-Lactam Antibiotics and Daptomycin against Methicillin-Resistant Staphylococcus aureus.

ABSTRACT: The evidence for using combination therapy for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections is growing. In this study, we investigated the synergistic effect of daptomycin (DAP) combined with piperacillin-tazobactam and ampicillin-sulbactam against MRSA in time-kill experiments. Six of eight strains demonstrated synergy between DAP and the ?-lactam-?-lactamase inhibitor (BLI) combination. In 5/8 strains, the synergy occurred only in the presence of the BLI, highlighting a role for BLIs in peptide-?-lactam synergy.

SUBMITTER: Henson KE 

PROVIDER: S-EPMC5192128 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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β-Lactamase Inhibitors Enhance the Synergy between β-Lactam Antibiotics and Daptomycin against Methicillin-Resistant Staphylococcus aureus.

Henson Karl Evans R KE   Yim Juwon J   Smith Jordan R JR   Sakoulas George G   Rybak Michael J MJ  

Antimicrobial agents and chemotherapy 20161227 1

The evidence for using combination therapy for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections is growing. In this study, we investigated the synergistic effect of daptomycin (DAP) combined with piperacillin-tazobactam and ampicillin-sulbactam against MRSA in time-kill experiments. Six of eight strains demonstrated synergy between DAP and the β-lactam-β-lactamase inhibitor (BLI) combination. In 5/8 strains, the synergy occurred only in the presence of the B  ...[more]

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