Ontology highlight
ABSTRACT:
SUBMITTER: Delvecchio R
PROVIDER: S-EPMC5192383 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Delvecchio Rodrigo R Higa Luiza M LM Pezzuto Paula P Valadão Ana Luiza AL Garcez Patrícia P PP Monteiro Fábio L FL Loiola Erick C EC Dias André A AA Silva Fábio J M FJ Aliota Matthew T MT Caine Elizabeth A EA Osorio Jorge E JE Bellio Maria M O'Connor David H DH Rehen Stevens S de Aguiar Renato Santana RS Savarino Andrea A Campanati Loraine L Tanuri Amilcar A
Viruses 20161129 12
Zika virus (ZIKV) infection in utero might lead to microcephaly and other congenital defects. Since no specific therapy is available thus far, there is an urgent need for the discovery of agents capable of inhibiting its viral replication and deleterious effects. Chloroquine is widely used as an antimalarial drug, anti-inflammatory agent, and it also shows antiviral activity against several viruses. Here we show that chloroquine exhibits antiviral activity against ZIKV in Vero cells, human brain ...[more]