Ion Channel Activity of Vpu Proteins Is Conserved throughout Evolution of HIV-1 and SIV.
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ABSTRACT:
SUBMITTER: Greiner T
PROVIDER: S-EPMC5192386 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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Ion Channel Activity of Vpu Proteins Is Conserved throughout Evolution of HIV-1 and SIV.
Greiner Timo T Bolduan Sebastian S Hertel Brigitte B Groß Christine C Hamacher Kay K Schubert Ulrich U Moroni Anna A Thiel Gerhard G
Viruses 20161201 12
The human immunodeficiency virus type 1 (HIV-1) protein Vpu is encoded exclusively by HIV-1 and related simian immunodeficiency viruses (SIVs). The transmembrane domain of the protein has dual functions: it counteracts the human restriction factor tetherin and forms a cation channel. Since these two functions are causally unrelated it remains unclear whether the channel activity has any relevance for viral release and replication. Here we examine structure and function correlates of different Vp ...[more]
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