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Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai.


ABSTRACT: Two new diphenylketones (1 and 2), a new xanthone (3), and a known xanthone analogue (4) were isolated and identified from Talaromyces islandicus EN-501, an endophytic fungus obtained from the fresh collected marine red alga Laurencia okamurai. Their structures were elucidated on the basis of NMR spectroscopic and X-ray crystallographic analysis. The joint isolation of benzophenones and xanthones from the same fungal strain supports the biogenesis of xanthones via a benzophenone intermediate. It is worth mentioning that xanthones 3 and 4 have a methyl group at C-6 and C-2, respectively, which is uncommon compared with typical xanthones usually having a methyl group at C-8. Compounds 1-4 exhibited potent antioxidative activities against DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonate) radicals with IC50 values ranging from 0.58 to 6.92 ?g/mL, which are stronger than that of the positive controls BHT (butylated hydroxytoluene) and ascorbic acid. Compounds 1, 3, and 4 also showed inhibitory activities against several pathogenic bacteria.

SUBMITTER: Li HL 

PROVIDER: S-EPMC5192460 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai.

Li Hong-Lei HL   Li Xiao-Ming XM   Liu Hui H   Meng Ling-Hong LH   Wang Bin-Gui BG  

Marine drugs 20161207 12


Two new diphenylketones (<b>1</b> and <b>2</b>), a new xanthone (<b>3</b>), and a known xanthone analogue (<b>4</b>) were isolated and identified from <i>Talaromyces islandicus</i> EN-501, an endophytic fungus obtained from the fresh collected marine red alga <i>Laurencia okamurai</i>. Their structures were elucidated on the basis of NMR spectroscopic and X-ray crystallographic analysis. The joint isolation of benzophenones and xanthones from the same fungal strain supports the biogenesis of xan  ...[more]

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