Integrating Clinical Phenotype and Gene Expression Data to Prioritize Novel Drug Uses.
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ABSTRACT:
SUBMITTER: Paik H
PROVIDER: S-EPMC5192994 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Integrating Clinical Phenotype and Gene Expression Data to Prioritize Novel Drug Uses.
Paik H H Chen B B Sirota M M Hadley D D Butte A J AJ
CPT: pharmacometrics & systems pharmacology 20161114 11
Drug repositioning has been based largely on genomic signatures of drugs and diseases. One challenge in these efforts lies in connecting the molecular signatures of drugs into clinical responses, including therapeutic and side effects, to the repurpose of drugs. We addressed this challenge by evaluating drug-drug relationships using a phenotypic and molecular-based approach that integrates therapeutic indications, side effects, and gene expression profiles induced by each drug. Using cosine simi ...[more]
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