A Mathematical Modeling Approach to Understanding the Effect of Anti-Interleukin Therapy on Eosinophils.
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ABSTRACT:
SUBMITTER: Karelina T
PROVIDER: S-EPMC5192997 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
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A Mathematical Modeling Approach to Understanding the Effect of Anti-Interleukin Therapy on Eosinophils.
Karelina T T Voronova V V Demin O O Colice G G Agoram B M BM
CPT: pharmacometrics & systems pharmacology 20161101 11
Emerging T-helper type 2 (Th<sub>2</sub> ) cytokine-based asthma therapies, such as tralokinumab, lebrikizumab (anti-interleukin (IL)-13), and mepolizumab (anti-IL-5), have shown differences in their blood eosinophil (EOS) response. To better understand these effects, we developed a mathematical model of EOS dynamics. For the anti-IL-13 therapies, lebrikizumab and tralokinumab, the model predicted an increase of 30% and 10% in total and activated EOS in the blood, respectively, and a decrease in ...[more]
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