Autonomic nervous infiltration positively correlates with pathological risk grading and poor prognosis in patients with lung adenocarcinoma.

ABSTRACT:

Background

Perineural invasion has been found in several types of human tumors, and is associated with poor prognosis; however, few studies have examined perineural invasion in lung cancer. We evaluated the relationship between autonomic nervous densities, pathological risk grading, and prognosis in patients with lung adenocarcinoma (LADC).

Methods

Neural fiber expression was examined by immunofluorescence in resected lung specimens in control patients (n = 30), and low-risk (n = 22), and high-risk LADC patients (n = 43). The nerve densities of normal lung tissue and abnormal lung tissues in the tumor and surrounding tissues were evaluated by a semi-quantitative score method.

Results

Increased sympathetic fibers mainly infiltrated the paratumoral area, while increased

SUBMITTER: Shao JX 

PROVIDER: S-EPMC5193011 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature