Non-invasive imaging using reporter genes altering cellular water permeability.
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ABSTRACT:
SUBMITTER: Mukherjee A
PROVIDER: S-EPMC5196229 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Non-invasive imaging using reporter genes altering cellular water permeability.
Mukherjee Arnab A Wu Di D Davis Hunter C HC Shapiro Mikhail G MG
Nature communications 20161223
Non-invasive imaging of gene expression in live, optically opaque animals is important for multiple applications, including monitoring of genetic circuits and tracking of cell-based therapeutics. Magnetic resonance imaging (MRI) could enable such monitoring with high spatiotemporal resolution. However, existing MRI reporter genes based on metalloproteins or chemical exchange probes are limited by their reliance on metals or relatively low sensitivity. Here we introduce a new class of MRI reporte ...[more]
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