Ontology highlight
ABSTRACT:
SUBMITTER: Caetano-Anolles D
PROVIDER: S-EPMC5198078 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Caetano-Anollés Derek D Caetano-Anollés Gustavo G
Life (Basel, Switzerland) 20161202 4
The origin of biomolecular machinery likely centered around an ancient and central molecule capable of interacting with emergent macromolecular complexity. tRNA is the oldest and most central nucleic acid molecule of the cell. Its co-evolutionary interactions with aminoacyl-tRNA synthetase protein enzymes define the specificities of the genetic code and those with the ribosome their accurate biosynthetic interpretation. Phylogenetic approaches that focus on molecular structure allow reconstructi ...[more]