Ontology highlight
ABSTRACT:
SUBMITTER: Morry J
PROVIDER: S-EPMC5198743 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Morry Jingga J Ngamcherdtrakul Worapol W Yantasee Wassana W
Redox biology 20161216
Oxidative stress, mainly contributed by reactive oxygen species (ROS), has been implicated in pathogenesis of several diseases. We review two primary examples; fibrosis and cancer. In fibrosis, ROS promote activation and proliferation of fibroblasts and myofibroblasts, activating TGF-β pathway in an autocrine manner. In cancer, ROS account for its genomic instability, resistance to apoptosis, proliferation, and angiogenesis. Importantly, ROS trigger cancer cell invasion through invadopodia forma ...[more]