Ontology highlight
ABSTRACT:
SUBMITTER: Ikeda M
PROVIDER: S-EPMC5198948 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Ikeda Masafumi M Sato Akihiro A Mochizuki Nobuo N Toyosaki Kayo K Miyoshi Chika C Fujioka Rumi R Mitsunaga Shuichi S Ohno Izumi I Hashimoto Yusuke Y Takahashi Hideaki H Hasegawa Hiromi H Nomura Shogo S Takahashi Ryuji R Yomoda Satoshi S Tsuchihara Katsuya K Kishino Satoshi S Esumi Hiroyasu H
Cancer science 20161219 12
GBS-01, an extract from the fruit of Arctium lappa L. is an orally administered drug rich in arctigenin, which has been reported to exert antitumor activity by attenuating the tolerance of cancer cells to glucose deprivation. We investigated the maximum tolerated dose of GBS-01 based on the frequency of the dose-limiting toxicities (DLTs) and pharmacokinetics in patients with advanced pancreatic cancer refractory to gemcitabine. GBS-01 was given orally at escalating doses from 3.0 g (containing ...[more]