Ontology highlight
ABSTRACT:
SUBMITTER: Yao N
PROVIDER: S-EPMC5199024 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
JSM biochemistry and molecular biology 20160530 1
Cellular genomic DNA is replicated by a multiprotein replisome machine. The replisome contains numerous essential factors that unwind, prime and synthesize each of the two strands of duplex DNA. The antiparallel structure of DNA, and unidirectional activity of DNA polymerases, requires the two strands of DNA to be extended in opposite directions, and this structural feature requires distinctive processes for synthesis of the two strands. Genome duplication is of central importance to all cell ty ...[more]