Ontology highlight
ABSTRACT:
SUBMITTER: Atherton JF
PROVIDER: S-EPMC5199195 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
eLife 20161220
The subthalamic nucleus (STN) is an element of cortico-basal ganglia-thalamo-cortical circuitry critical for action suppression. In Huntington's disease (HD) action suppression is impaired, resembling the effects of STN lesioning or inactivation. To explore this potential linkage, the STN was studied in BAC transgenic and Q175 knock-in mouse models of HD. At <2 and 6 months of age autonomous STN activity was impaired due to activation of K<sub>ATP</sub> channels. STN neurons exhibited prolonged ...[more]