A Nanobody Activation Immunotherapeutic that Selectively Destroys HER2-Positive Breast Cancer Cells.
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ABSTRACT:
SUBMITTER: Gray MA
PROVIDER: S-EPMC5199233 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
A Nanobody Activation Immunotherapeutic that Selectively Destroys HER2-Positive Breast Cancer Cells.
Gray Melissa A MA Tao Ran N RN DePorter Sandra M SM Spiegel David A DA McNaughton Brian R BR
Chembiochem : a European journal of chemical biology 20151210 2
We report a rationally designed nanobody activation immunotherapeutic that selectively redirects anti-dinitrophenyl (anti-DNP) antibodies to the surface of HER2-positive breast cancer cells, resulting in their targeted destruction by antibody-dependent cellular cytotoxicity. As nanobodies are relatively easy to express, stable, can be humanized, and can be evolved to potently and selectively bind virtually any disease-relevant cell surface receptor, we anticipate broad utility of this therapeuti ...[more]
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