Ontology highlight
ABSTRACT:
SUBMITTER: Zhen A
PROVIDER: S-EPMC5199686 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Zhen Anjie A Rezek Valerie V Youn Cindy C Lam Brianna B Chang Nelson N Rick Jonathan J Carrillo Mayra M Martin Heather H Kasparian Saro S Syed Philip P Rice Nicholas N Brooks David G DG Kitchen Scott G SG
The Journal of clinical investigation 20161212 1
Chronic immune activation, immunosuppression, and T cell exhaustion are hallmarks of HIV infection, yet the mechanisms driving these processes are unclear. Chronic activation can be a driving force in immune exhaustion, and type I interferons (IFN-I) are emerging as critical components underlying ongoing activation in HIV infection. Here, we have tested the effect of blocking IFN-I signaling on T cell responses and virus replication in a murine model of chronic HIV infection. Using HIV-infected ...[more]