Ontology highlight
ABSTRACT:
SUBMITTER: Nakaya M
PROVIDER: S-EPMC5199696 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Nakaya Michio M Watari Kenji K Tajima Mitsuru M Nakaya Takeo T Matsuda Shoichi S Ohara Hiroki H Nishihara Hiroaki H Yamaguchi Hiroshi H Hashimoto Akiko A Nishida Mitsuho M Nagasaka Akiomi A Horii Yuma Y Ono Hiroki H Iribe Gentaro G Inoue Ryuji R Tsuda Makoto M Inoue Kazuhide K Tanaka Akira A Kuroda Masahiko M Nagata Shigekazu S Kurose Hitoshi H
The Journal of clinical investigation 20161205 1
Myocardial infarction (MI) results in the generation of dead cells in the infarcted area. These cells are swiftly removed by phagocytes to minimize inflammation and limit expansion of the damaged area. However, the types of cells and molecules responsible for the engulfment of dead cells in the infarcted area remain largely unknown. In this study, we demonstrated that cardiac myofibroblasts, which execute tissue fibrosis by producing extracellular matrix proteins, efficiently engulf dead cells. ...[more]