Ontology highlight
ABSTRACT:
SUBMITTER: Fei HJ
PROVIDER: S-EPMC5199753 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Fei Hong-Jun HJ Zu Li-Dong LD Wu Jun J Jiang Xiao-Shu XS Wang Jing-Long JL Chin Y Eugene YE Fu Guo-Hui GH
American journal of cancer research 20161201 12
Gastric cancer (GC) is a leading cause of cancer-related death worldwide and the pathogenesis of GC remains largely unknown. Here, we demonstrate a novel mechanism by which P300/CBP associating factor (PCAF) acts as a tumor suppressor in GC cells. We showed that both PCAF mRNA and protein were downregulated in GC cells, and that this downregulation correlated with poor survival. Meanwhile, the interaction between human anion exchanger 1 (AE1) and p16 is a key event in GC development. We found th ...[more]