Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis.

ABSTRACT: A number of health and lifestyle factors are thought to contribute to cognitive decline associated with age but cannot be easily modified by the individual patient. We identified 12 individually modifiable interventions that can be implemented during midlife or later with the potential to ameliorate cognitive aging. For ten of these, we used PubMed databases for a systematic review of long-duration (at least 6 months), randomized, controlled trials in midlife and older adults without dementia or mild cognitive impairment with objective measures of neuropsychological performance. Using network meta-analysis, we performed a quantitative synthesis for global cognition (primary outcome) and episodic memory (secondary outcome). Of 1038 publications identified by our search strategy, 24 eligible

SUBMITTER: Lehert P 

PROVIDER: S-EPMC5199766 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature